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Zhuang, Xiaoxi
One or more keywords matched the following properties of Zhuang, Xiaoxi
PropertyValue
keywords dopamine, basal ganglia, plasticity, learning, memory, neurological disorders, psychiatric disorders
overview We investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.
One or more keywords matched the following items that are connected to Zhuang, Xiaoxi
Item TypeName
Concept Association Learning
Concept Epilepsy
Concept Fragile X Syndrome
Concept Obesity
Concept Dopamine
Concept Functional Laterality
Concept Movement Disorders
Concept Tobacco Use Disorder
Concept Starvation
Concept Dopamine Agents
Concept Nerve Degeneration
Concept Oxidative Stress
Concept Maze Learning
Concept Parkinson Disease
Concept Disease Models, Animal
Concept Learning
Concept Receptors, Dopamine D2
Concept Dopamine Plasma Membrane Transport Proteins
Academic Article Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.
Academic Article Targeted gene expression in dopamine and serotonin neurons of the mouse brain.
Academic Article Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.
Academic Article Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.
Academic Article Dopamine scales performance in the absence of new learning.
Academic Article Dopamine-dependent motor learning: insight into levodopa's long-duration response.
Academic Article Dopaminergic enhancement of local food-seeking is under global homeostatic control.
Academic Article Taste uncoupled from nutrition fails to sustain the reinforcing properties of food.
Academic Article A cAMP pathway underlying reward prediction in associative learning.
Academic Article Tonic dopamine modulates exploitation of reward learning.
Academic Article Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources.
Academic Article A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.
Academic Article The role of neuroplasticity in dopaminergic therapy for Parkinson disease.
Academic Article A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.
Academic Article Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons.
Academic Article Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency.
Academic Article Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.
Academic Article Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Concept Dopamine D2 Receptor Antagonists
Grant Drosophila and mouse models of PNPO deficiency
Grant Reward mechanisms in feeding and obesity
Grant Dynamics of m6A methylated Arc mRNA
Grant RNA methylation in synaptic plasticity and drug-seeking
Grant Targeting adenylyl cyclase to prevent L-DOPA-induced dyskinesia
Grant Nicotine mitigates dopamine blockade-induced aberrant plasticity and learning
Grant Animal models of dopamine-independent motor control
Grant Gene Dose Effect of DJ-1 and PINK1 on Tissue Degeneration
Grant Preventing Experience Dependent Aberrant Plasticity Under Dopamine Deficiency
Grant Genetic dissection of neural pathways for appetitive associative learning
Grant GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROL
Grant Epigenetic Mechanisms in Motor Habits Stability
Search Criteria
  • dopamine
  • basal ganglia
  • plasticity
  • learning
  • memory
  • neurological disorders
  • psychiatric
  • disorders